| Identification | Back Directory | [Name]
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- | [CAS]
4551-00-2 | [Synonyms]
NSC-70220
SOS1 inhibitor 1
9H-Fluorene,9-[3-(2-nitrophenyl)-2-propen-1-ylidene]- | [Molecular Formula]
C22H15NO2 | [MDL Number]
MFCD00032941 | [MOL File]
4551-00-2.mol | [Molecular Weight]
325.36 |
| Chemical Properties | Back Directory | [Melting point ]
186 °C | [Boiling point ]
569.6±49.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: 12.5 mg/mL (38.42 mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
NSC-70220 is a selective and allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation, and partially inhibited catalytic site activation. NSC-70220 has an anticancer effect[1]. | [Biological Activity]
NSC-70220 is a selective allosteric SOS1 inhibitor. It has an anticancer effects and inhibits allosteric site activation and partially inhibits catalytic site activation. | [in vitro]
The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with NSC-70220 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of NSC-70220 and NSC-658497 on cell growth It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of NSC-70220 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of NSC-70220 overnight resulted in lower expression levels of P-ERK. | [target]
| [References]
[1] ARYL SULFONOHYDRAZIDES. WO 2016077793A1. |
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