| Identification | Back Directory | [Name]
carbomycin | [CAS]
4564-87-8 | [Synonyms]
M 4209
Nsc51001
NSC 55924
MagnaMycin
carbomycin
Aids012086
Aids-012086
Magnamycin a
CarboMycin A
DeltaMycin A4
Carbomycin
DISCONTINUED
(12S,13S)-9-Deoxy-12,13-epoxy-12,13-dihydro-9-oxoleucoMycin V 3-Acetate 4B-(3-Methylbutanoate)
Leucomycin V, 9-deoxy-12,13-epoxy-12,13-dihydro-9-oxo-, 3-acetate 4B-(3-methylbutanoate), (12S,13S)-
3-Methyl-butyric acid 6-{[(Z)-7-acetoxy-8-methoxy-3,12-dimethyl-5,13-dioxo-10-(2-oxo-ethyl)-4,17-dioxa-bicyclo[14.1.0]heptadec-14-en-9-yloxy]-dimethylamino-hydroxy-methyl-tetrahydro-pyran-3-yloxy}-4-hydroxy-2,4-dimethyl-tetrahydro-pyran-3-yl ester | [Molecular Formula]
C42H67NO16 | [MDL Number]
MFCD01716264 | [MOL File]
4564-87-8.mol | [Molecular Weight]
841.982 |
| Chemical Properties | Back Directory | [Definition]
An antibiotic isolated from products of Strepto-
myces halstedii when grown in suitable media
by the deep-culture method. It inhibits growth of
certain gram-positive bacteria such as staphylo-
cocci, pneumococci, and hemolytic streptococci.
| [Melting point ]
214° | [alpha ]
D25 -58.6° (chloroform) | [Boiling point ]
769.45°C (rough estimate) | [density ]
1.1761 (rough estimate) | [refractive index ]
1.6220 (estimate) | [pka]
pKb 7.2(at 25℃) |
| Hazard Information | Back Directory | [Uses]
Sixteen-membered-ring macrolite antibiotic complex similar to Leucomycin and Erythromycin, produced by Stroptomyces halstedii. | [Brand name]
Magnamycin
(Pfizer). | [Originator]
Magnamycin,Pfizer,US,1953 | [Manufacturing Process]
A selected strain of Streptomyces halstedii was cultivated in an aqueous
nutrient medium under aerobic conditions and the resulting broth containing
carbomycin antibiotics was filtered. The solutions was extracted twice at pH
6.5 with one-quarter volume of methyl isobutyl ketone. The combined extracts
were concentrated to one-tenth volume under vacuum, and the antibiotics
were extracted into water adjusted to a pH of about 2 with sulfuric acid. After
adjusting the separated aqueous solution to pH 6.5, the antibiotic was
extracted into benzene and the solution was concentrated to a small volume.
Addition of hexane resulted in the separation of a solid product containing the
benzene complexes of carbomycin A and carbomycin B, present in the
fermentation broth. | [Therapeutic Function]
Antibiotic |
| Safety Data | Back Directory | [Safety Profile]
Poison by
subcutaneous route. Moderately toxic by
intravenous and intramuscular routes. When
heated to decomposition it emits toxic
fumes of NOx. | [Toxicity]
LD50 i.v. in mice: 550 mg/kg (Tanner) |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|