| Identification | Back Directory | [Name]
[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
457631-44-6 | [Synonyms]
4-(2-Aminoethyl)-N-Boc-aniline
tert-Butyl (4-(2-aminoethyl)phenyl)carbamate
[4-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER
Carbamic acid, N-[4-(2-aminoethyl)phenyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H20N2O2 | [MDL Number]
MFCD09701235 | [MOL File]
457631-44-6.mol | [Molecular Weight]
236.31 |
| Chemical Properties | Back Directory | [Melting point ]
89-91 °C | [Boiling point ]
315.9±25.0 °C(Predicted) | [density ]
1.099±0.06 g/cm3(Predicted) | [storage temp. ]
Store at Room Tem. | [pka]
13.79±0.70(Predicted) | [Appearance]
white to off-white solid |
| Hazard Information | Back Directory | [Synthesis]
[4-(2-Amino-ethyl)-phenyl]-carbamic acid tert-butyl ester is synthesised using 4-tert-butoxycarbonylaminophenylacetonitrile as a raw material by chemical reaction. The specific synthesis steps are as follows:
To a solution of (300 gm, 1.29 moles) N-BOC-4-aminophenylacetonitrile in 3000 ml of methanol, 25% aq. ammonia solution (480 ml) and Raney nickel (45 gm) were added at 25 -30°C. Reaction mixture was subjected to hydrogenation at 50-60 PSI for 4 hrs. After completion of reaction, as indicated from TLC, reaction mixture was filtered and washed with (2 X 25 ml) methanol. Filtrate was concentrated under vacuum and resulting residue was treated with (1500 ml) 1M aq. hydrochloric acid at 25-30°C. Reaction mixture was stirred for 15 minutes and filtered to remove insoluble impurities. Filtrate was basified to pH 10-12 with 50% aq. NaOH solution below 25°C. Precipitated 4-(2-aminoethyl)-N-(tert-butoxycarbonyl) phenylamine was filtered and washed with (2 X 100 ml) water. Solid was dried under vacuum at 55- 60°C for 8-10 hrs. Dry weight: 240 gm (79%). 1H NMR (CDC13 and 400 MHz): δ 1.11 (2H, s), 1.51 (9H, s), 2.68 (2H, t), 2.93 (2H, t), 6.72 (1H, s), 7.10 (2H, d), 7.28 (2H, d).
![[4-(2-Amino-ethyl)-phenyl]-carbamic acid tert-butyl ester synthesis](/NewsImg/2024-01-29/6384213210552037274683100.png "[4-(2-Amino-ethyl)-phenyl]-carbamic acid tert-butyl ester synthesis") |
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| Company Name: |
BePharm Ltd
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| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
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