| Identification | Back Directory | [Name]
3,5-Pyrazolidinedione, 4-[(2-chlorophenyl)methylene]-1-phenyl- | [CAS]
4590-86-7 | [Synonyms]
DOCK2-IN-1
4-<2-Chlor-benzyliden>-1-phenyl-pyrazolidindion-3,5
4-(2-Chlorobenzylidene)-1-phenylpyrazolidine-3,5-dione
3,5-Pyrazolidinedione, 4-[(2-chlorophenyl)methylene]-1-phenyl- | [Molecular Formula]
C16H11ClN2O2 | [MOL File]
4590-86-7.mol | [Molecular Weight]
298.72 |
| Hazard Information | Back Directory | [Uses]
DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1]. | [IC 50]
DOCK2 | [References]
[1] Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97. DOI:10.1016/j.chembiol.2012.03.008 |
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