| Identification | Back Directory | [Name]
1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-(1E,3E)-1,3-hexadien-1-yl-8,9-dihydroxy-3-methyl-8-(phenylmethyl)-, (5S,8R,9R)- | [CAS]
461644-34-8 | [Synonyms]
1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-(1E,3E)-1,3-hexadien-1-yl-8,9-dihydroxy-3-methyl-8-(phenylmethyl)-, (5S,8R,9R)- | [Molecular Formula]
C21H23NO5 | [MOL File]
461644-34-8.mol | [Molecular Weight]
369.41 |
| Chemical Properties | Back Directory | [Melting point ]
165.5-166.0 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | [Boiling point ]
635.0±55.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [pka]
16.37±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Azaspirene ((-)-Azaspirene) is an angiogenesis and Raf-1 activation inhibitor isolated from the fungus Neosartorya sp. Azaspirene inhibits vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) migration and Raf-1 activation, but has no effect on the activation of kinase insert domain-containing receptor/fetal liver kinase 1 (VEGF receptor 2)[1]. | [References]
[1] Asami Y, et al. Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Cancer Sci. 2008 Sep;99(9):1853-8. DOI:10.1111/j.1349-7006.2008.00890.x |
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