| Identification | Back Directory | [Name]
verrucarin J | [CAS]
4643-58-7 | [Synonyms]
Verrucrin J
verrucarin J
Verrucarin J
DISCONTINUED
Verrucarin A, 2',3'-didehydro-2'-deoxy-, (2'E)- | [Molecular Formula]
C27H32O8 | [MOL File]
4643-58-7.mol | [Molecular Weight]
484.54 |
| Chemical Properties | Back Directory | [alpha ]
D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform) | [Boiling point ]
735.4±60.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [solubility ]
Dichloromethane: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble | [form ]
powder | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune. | [Definition]
ChEBI: Verrucarin j is a trichothecene. | [in vivo]
Verrucarin J (0.5?mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis[5]. | Animal Model: | 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts[2] | | Dosage: | 0.5?mg/kg body weight | | Administration: | i.p. for 4 weeks | | Result: | Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors. |
| Animal Model: | Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts[5] | | Dosage: | 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate) | | Administration: | i.p. for three weeks after 10 days of injection of A2780 cells | | Result: | Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.
Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg.
Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg.
In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.
|
| [References]
[1] MINH VAN NGUYEN. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi[J]. Journal of Antibiotics, 2022, 75 9: 514-518. DOI: 10.1038/s41429-022-00541-7
[2] KAREN UDOH. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.[J]. Stem Cell Reviews and Reports, 2019, 15 4: 601-611. DOI: 10.1007/s12015-019-09874-7
[3] DEEKSHA PAL. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer.[J]. ACS Biomaterials Science & Engineering, 2018: 798. DOI: 10.1038/s41419-018-0810-8 |
|
|