| Identification | Back Directory | [Name]
(R)-4-METHOXYDALBERGIONE | [CAS]
4646-86-0 | [Synonyms]
(R)-4-METHOXYDALBERGIONE
(+)-4-Methoxydalbergione
2-[(αR)-α-Vinylbenzyl]-5-methoxy-1,4-benzoquinone
2-[(R)-1-Phenyl-2-propenyl]-5-methoxy-1,4-benzoquinone
2-[(1R)-1-Phenyl-2-propenyl]-5-methoxy-1,4-benzoquinone
2,5-Cyclohexadiene-1,4-dione, 2-methoxy-5-[(1R)-1-phenyl-2-propen-1-yl]- | [Molecular Formula]
C16H14O3 | [MOL File]
4646-86-0.mol | [Molecular Weight]
254.28 |
| Hazard Information | Back Directory | [Description]
(R)-4-Methoxy dalbergione is the main allergen of
Dalbergia nigra and Dalbergia latifolia Roxb. (East
Indian rosewood, palissandre). Occupational sensitization
occurs in timberworkers.
| [Uses]
(R)-4-Methoxydalbergione is a urease inhibitor with IC50s of 59.72 and 67.33 μM for Bacillus pasteurii urease and Jack bean urease. (R)-4-Methoxydalbergione also has antiplasmodial activity. (R)-4-Methoxydalbergione can be isolated from Ranunculus repens[1][2]. | [Definition]
ChEBI: (R)-4''-methoxydalbergione is a member of the class of 1,4-benzoquinones that is p-benzoquinone substituted by a methoxy group at position 2 and a 1-phenylallyl group at position 5. Isolated from the heartwood of Dalbergia louveli, it exhibits antiplasmodial activity. It has a role as a metabolite and an antiplasmodial drug. It is an enol ether and a member of 1,4-benzoquinones. | [References]
[1] Khan WN, et al. New natural urease inhibitors from Ranunculus repens. J Enzyme Inhib Med Chem. 2006 Feb;21(1):17-9. DOI:10.1080/14756360500319210 |
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