| Identification | Back Directory | [Name]
4-(2-Bromoethyl)-tetrahydropyran | [CAS]
4677-20-7 | [Synonyms]
4-(2-broMoethyl)oxane
4-(2-Bromoethyl)-tetrahydropyran
Pyran, 4-(2-bromoethyl)tetrahydro-
4-(2-Bromoethyl)tetrahydro-2H-pyran
2H-Pyran, 4-(2-bromoethyl)tetrahydro-
tert-butyl 3-allyl-3-hydroxyazetidine-75-carboxylate | [Molecular Formula]
C7H13BrO | [MDL Number]
MFCD09800414 | [MOL File]
4677-20-7.mol | [Molecular Weight]
193.082 |
| Chemical Properties | Back Directory | [Boiling point ]
224℃ | [density ]
1.302 | [Fp ]
89℃ | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-bromoethyltetrahydropyran from the compound (CAS: 428871-01-6): lithium bromide (29.7 g, 56.9 mmol) was added to a stirred solution of ethyl 2-(4-oxo)methanesulfonate (11.9 g, 56.9 mmol) in anhydrous acetone (300 mL). The reaction was refluxed under nitrogen (N2) atmosphere for 5 hours. Upon completion of the reaction, the acetone was removed by rotary evaporation, water (150 mL) was added, and the mixture was extracted with dichloromethane (2 x 100 mL). The organic extracts were combined, dried with potassium carbonate (K2CO3), filtered and concentrated by rotary evaporation to give a light brown oil. The crude product was purified by distillation (65 °C, 0.2 mmHg) to give 8.06 g of colorless oil in 73.3% yield. | [References]
[1] Journal of Organic Chemistry, 2006, vol. 71, # 26, p. 9909 - 9911
[2] Patent: US2004/220214, 2004, A1
[3] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 76
[4] Patent: WO2016/44626, 2016, A1. Location in patent: Paragraph 00487
[5] Patent: WO2008/101867, 2008, A1. Location in patent: Page/Page column 71 |
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