| Identification | Back Directory | [Name]
elsilimomab | [CAS]
468715-71-1 | [Synonyms]
B-E8
elsilimomab
Immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 kappa-chain, dimer |
| Hazard Information | Back Directory | [Uses]
Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA)[1][2][3]. | [IC 50]
IL-6: 1.4 nM (IC50) | [References]
[1] Lee JJ, et al. A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol Ther. 2014 Jul;22(7):1254-1265. DOI:10.1038/mt.2014.59
[2] Burger R, et al. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth. Haematologica. 2017 Feb;102(2):381-390. DOI:10.3324/haematol.2016.145060
[3] Finch DK, et al. Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol. 2011 Aug 26;411(4):791-807. DOI:10.1016/j.jmb.2011.06.031 |
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