| Identification | Back Directory | [Name]
tolbutamide sodium | [CAS]
473-41-6 | [Synonyms]
tolbutamide sodium
TolbutaMide sodiuM salt
Benzenesulfonamide, N-(butylamino)carbonyl-4-methyl-, monosodium salt | [Molecular Formula]
C12H18N2NaO3S | [MDL Number]
MFCD01676730 | [MOL File]
473-41-6.mol | [Molecular Weight]
293.338 |
| Hazard Information | Back Directory | [Uses]
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2]. | [General Description]
Tolbutamide sodium,1-butyl-3-(p-tolylsulfonyl)urea monosodium salt (OrinaseDiagnostic), is a white, crystalline powder, freely soluble inwater, soluble in alcohol and chloroform, and very slightlysoluble in ether. | [Clinical Use]
This water-soluble salt of tolbutamide is used intravenouslyfor the diagnosis of mild diabetes mellitus and offunctioning pancreatic islet cell adenomas. The sterile drypowder is dissolved in sterile water for injection to make aclear solution, which then should be administered within1 hour. The main route of breakdown is to butylamine andsodium p-toluene sulfonamide. | [References]
[1] Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407(5):493-9. DOI:10.1007/BF00657506
[2] Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273(50):33501-7. DOI:10.1074/jbc.273.50.33501 |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
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| Telephone: |
+86-29-81139210 17389186172 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-219/ |
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