| Identification | Back Directory | [Name]
KETOMALONIC ACID | [CAS]
473-90-5 | [Synonyms]
mesoxalate
mesoxalicacid
oxomalonicacid
KETOMALONIC ACID
2-oxomalonicacid
2-ketomalonic acid
oxopropanedioicacid
alpha-ketomalonicacid
2-Oxopropanedioic acid
Propanedioic acid, 2-oxo-
Dihydroxypropanedioic acid
2,2-Dihydroxypropanedioic acid
Ketomalonic acid monohydrate,99% | [EINECS(EC#)]
207-473-4 | [Molecular Formula]
C3H2O5 | [MDL Number]
MFCD00002578 | [MOL File]
473-90-5.mol | [Molecular Weight]
118.04 |
| Hazard Information | Back Directory | [Uses]
Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2]. | [Definition]
ChEBI: Oxomalonic acid is an oxo dicarboxylic acid. It is functionally related to a malonic acid. It is a conjugate acid of an oxomalonate(1-). | [References]
[1] Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84. DOI:10.1074/jbc.M114.614305
[2] W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. DOI:10.1021/bi0015764 |
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