| Identification | Back Directory | [Name]
6-chloro-N-(4-ethoxyphenyl)-2-methylquinolin-1-ium-4-amine chloride | [CAS]
474084-56-5 | [Synonyms]
6-chloro-N-(4-ethoxyphenyl)-2-methylquinolin-1-ium-4-amine chloride | [Molecular Formula]
C18H18Cl2N2O | [MOL File]
474084-56-5.mol | [Molecular Weight]
349.26 |
| Hazard Information | Back Directory | [Description]
CSV0C018875 Hydrochloride is a novel G9a (EHMT2) inhibitor, binding tightly inside the active site cavity of G9a, inhibiting the activity of G9a in both enzyme and cell based assays with much lesser toxicity than BIX-0129. | [Uses]
CSV0C018875 hydrochloride is a G9a (EHMT2) inhibitor that inhibits G9a activity. CSV0C018875 can effectively inhibit G9a activity in both enzyme and cell-based assays, and its toxicity is much lower than that of the known G9a inhibitor BIX-01294. CSV0C018875 binds tightly to the active site cavity of G9a, thereby improving the binding firmness and prolonging the residence time of the compound, further enhancing the inhibitory effect of G9a. CSV0C018875 has the potential to improve its ADME (absorption, distribution, metabolism and excretion) and pharmacodynamic properties through further optimization[1]. | [References]
[1] M Ramya Chandar Charles, et al. Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening. Biochimie. 2020 Jan;168:220-230. DOI:10.1016/j.biochi.2019.11.006
[2] Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening DOI:10.1016/j.biochi.2019.11.006 |
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| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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