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474255-10-2

474255-10-2 Structure

474255-10-2 Structure
IdentificationBack Directory
[Name]

2-(4-(2-(4-methoxyphenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
[CAS]

474255-10-2
[Synonyms]

MM0299
2-(4-(2-(4-methoxyphenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
4,6-Ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 4,4a,5,5a,6,6a-hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]-
[Molecular Formula]

C26H23NO5
[MOL File]

474255-10-2.mol
[Molecular Weight]

429.46
Chemical PropertiesBack Directory
[Boiling point ]

693.0±55.0 °C(Predicted)
[density ]

1.336±0.06 g/cm3(Predicted)
[storage temp. ]

-10 to -25°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

powder
[pka]

-10.47±0.20(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Uses]

MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1].
[Biological Activity]

MM0299 is a cell penetrantselective and potent inhibitor of lanosterol synthase (LSS) th at exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumorswhich induces toxicity in glioma stem-like cells.
[References]

[1] Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. DOI:10.1016/j.chembiol.2023.01.005
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