Identification | Back Directory | [Name]
2-(4-(2-(4-methoxyphenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione | [CAS]
474255-10-2 | [Synonyms]
MM0299 2-(4-(2-(4-methoxyphenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione 4,6-Ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 4,4a,5,5a,6,6a-hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]- | [Molecular Formula]
C26H23NO5 | [MOL File]
474255-10-2.mol | [Molecular Weight]
429.46 |
Chemical Properties | Back Directory | [Boiling point ]
693.0±55.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
-10.47±0.20(Predicted) | [color ]
white to beige |
Hazard Information | Back Directory | [Uses]
MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 μM, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1]. | [Biological Activity]
MM0299 is a cell penetrantselective and potent inhibitor of lanosterol synthase (LSS) th at exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumorswhich induces toxicity in glioma stem-like cells. | [References]
[1] Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. DOI:10.1016/j.chembiol.2023.01.005 |
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Company Name: |
Merck KGaA
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Tel: |
21-20338288 |
Website: |
www.sigmaaldrich.cn |
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