| Identification | Back Directory | [Name]
C12 NBD-SPHINGOSINE, BETA-D-LACTOSYL | [CAS]
474943-06-1 | [Synonyms]
C12 NBD-SPHINGOSINE, B-D-LACTOSYL
C12 NBD-SPHINGOSINE, BETA-D-LACTOSYL
C12 NBD Lactosylceramide (d18:1/12:0)
C12 NBD-Sphingosine, beta-D-lactosylsphingosine
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)aMino]dodecanoyl]-D-lactosyl-1-1'-sphingosine
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-lactosyl-β1-1'-sphingosine
N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-D-LACTOSYL-1-1'-SPHINGOSINE;C12-NBD LACTOSYL CERAMIDE
Dodecanamide, N-[(1S,2R,3E)-1-[[(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-
N-[(E,2S,3R)-1-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3-hydroxyoctadec-4-en-2-yl]-12-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]dodecanamide | [Molecular Formula]
C48H81N5O16 | [MDL Number]
MFCD03452985 | [MOL File]
474943-06-1.mol | [Molecular Weight]
984.2 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Chloroform:Methanol (2:1): soluble | [form ]
A solid | [pka]
12.79±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
C12 NBD Lactosylceramide is a derivative of Lactosylceramide labeled with a C12 NBD fluorescent group. C12 NBD Lactosylceramide can be used to identify Lactosylceramides[1]. | [Biological Activity]
Lactosyl ceramide plays a key role in signaling cascades leading to phenotypic changes such as adhesionmigrationcell proliferationand angiogenesis. In vertebrateslactosyl ceramide is a major precursor for biosynthesis of glycosphingolipids involved in various vital cellular processes. Lactosyl ceramide is also known to be crucial for mediating osteoclastogenesis. | [References]
[1] Horibata Y, et al. Transglycosylation and reverse hydrolysis reactions of endoglycoceramidase from the jellyfish, Cyanea nozakii. J Biochem. 2001 Aug;130(2):263-8. DOI:10.1093/oxfordjournals.jbchem.a002981 |
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