| Identification | Back Directory | [Name]
D-lactosyl--1,1' N-lauroyl-D-erythro-sphingosine | [CAS]
474943-80-1 | [Synonyms]
C12 Lactosyl(ss) Ceramide(d18:1/12:0)
LacCer d18:1/12:0 (Galb1,4GlcbCeramide)
D-lactosyl--1,1' N-lauroyl-D-erythro-sphingosine
Dodecanamide, N-[(1S,2R,3E)-1-[[(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]- | [Molecular Formula]
C42H79NO13 | [MDL Number]
MFCD22416993 | [MOL File]
474943-80-1.mol | [Molecular Weight]
806.09 |
| Chemical Properties | Back Directory | [Boiling point ]
966.0±65.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.79±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
KNWHKVBHCLQVFX-NKNVVQMUSA-N | [SMILES]
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O |
| Hazard Information | Back Directory | [Uses]
Trihexosylceramide (d18:1/12:0) is a type of Trihexosylceramide. In the renal tissue of heterozygous Fabry's disease, the cytoplasm of glomerular epithelial cells appears foamy. Trihexosylceramide accumulated in glomerular epithelial cells as identified by immunostaining[1][2]. | [References]
[1] Wang JR, et al. Improved sphingolipidomic approach based on ultra-high performance liquid chromatography and multiple mass spectrometries with application to cellular neurotoxicity. Anal Chem. 2014 Jun 17;86(12):5688-96. DOI:10.1021/ac5009964
[2] Fukushima M, et al. A female heterozygous patient with Fabry's disease with renal accumulation of trihexosylceramide detected with a monoclonal antibody. Am J Kidney Dis. 1995 Dec;26(6):952-5. DOI:10.1016/0272-6386(95)90061-6 |
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