| Identification | Back Directory | [Name]
colchiceine | [CAS]
477-27-0 | [Synonyms]
NSC 3341
NSC 33411
colchiceine
O10-Demethylcolchicine
Colchicine EP Impurity F
(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide | [EINECS(EC#)]
207-512-5 | [Molecular Formula]
C21H23NO6 | [MOL File]
477-27-0.mol | [Molecular Weight]
385.414 |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Pale Yellow Solid | [Melting point ]
172-1740C | [alpha ]
D25 -255.1° (c = 1 in chloroform) | [Boiling point ]
511.86°C (rough estimate) | [density ]
1.2400 | [refractive index ]
1.5614 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.59±0.40(Predicted) | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Off- White to Pale Yellow Solid | [Uses]
A metabolite of Colchicine | [Description]
Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment
of gouty arthritis. It is especially useful in acute
attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol
or phenylbutazone. The drug is believed to act
by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including
phagocytosis and the release of inflammatory
mediators. The alkaloid is extremely toxic and
must be used with care. Gastrointestinal adverse
effects include nausea, vomiting, and diarrhea.
Blood disorders, including agranulocytosis and
aplastic anemia, sometimes are seen after prolonged administration of this drug. | [Definition]
ChEBI: Colchiceine is a cyclic ketone. | [Trade name]
Colchicina (Smith Kline,
Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major,
USA). |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
|