| Identification | Back Directory | [Name]
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(8H)-one, 5,9-dihydro-5-(3,4,5-trimethoxyphenyl)-, (5R)- | [CAS]
477-52-1 | [Synonyms]
β-Apopicropodophyllin
Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(8H)-one, 5,9-dihydro-5-(3,4,5-trimethoxyphenyl)-, (5R)- | [Molecular Formula]
C22H20O7 | [MOL File]
477-52-1.mol | [Molecular Weight]
396.39 |
| Chemical Properties | Back Directory | [Melting point ]
216 °C | [Boiling point ]
580.8±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder |
| Hazard Information | Back Directory | [Uses]
β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer[1]. | [in vivo]
β-Apopicropodophyllin (1 and 5 mg/kg; intra-tumorous injection; nude mice with xenografts) retards tumor growth in a dose-dependent manner[1]. | Animal Model: | nude mice with xenografts[1] | | Dosage: | 1 and 5 mg/kg | | Administration: | intra-tumorous injection | | Result: | Inhibited tumor growth of NSCLC xenografts in nude mice. |
| [References]
[1] Kim JY, et, al. A novel anti-cancer role of β-apopicropodophyllin against non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2018 Oct 15;357:39-49. DOI:10.1016/j.taap.2018.08.022 |
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| Company Name: |
Biorbyt Ltd.
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| Telephone: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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