| Identification | Back Directory | [Name]
2-AMINO-3-METHOXYPYRAZINE | [CAS]
4774-10-1 | [Synonyms]
3-methoxypyrazin-2-amine
3-Methoxy-2-pyrazinamine
2-AMINO-3-METHOXYPYRAZINE
2-Pyrazinamine, 3-methoxy-
3-METHOXYPYRAZIN-2-YLAMINE
2-AMINO-3-METHOXYPYRAZINE ISO 9001：2015 REACH | [Molecular Formula]
C5H7N3O | [MDL Number]
MFCD05722793 | [MOL File]
4774-10-1.mol | [Molecular Weight]
125.13 |
| Chemical Properties | Back Directory | [Melting point ]
84-85℃ | [Boiling point ]
241℃ | [density ]
1.224 | [Fp ]
100℃ | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
3.49±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-amino-3-methoxypyrazine from 2-amino-3-chloropyrazine is as follows:
Pre-step A: Synthesis of 3-methoxy-2-pyrazinamine
3-Chloro-2-pyrazinamine (200 mg, 1.544 mmol) and sodium methanol (250 mg, 4.63 mmol) were dissolved in methanol (3.9 mL) and the mixture was placed in a microwave reactor, heated to 130°C, and reacted for 60 min. Upon completion of the reaction, the crude product was purified by reversed-phase high performance liquid chromatography (RP-HPLC) to afford 3-methoxy-2-pyrazinamine (113 mg, 0.903 mmol, 59% yield). Mass spectrum (electrospray positive ion mode) m/z: 125.8 ([MH]+). | [References]
[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column |
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