| Identification | Back Directory | [Name]
Botiacrine | [CAS]
4774-53-2 | [Synonyms]
Botiacrine
10-[2-(Dimethylamino)ethylthiocarbonyl]-9,9-dimethylacridan
S-(2-dimethylaminoethyl) 9,9-dimethylacridine-10-carbothioate
9,9-dimethylacridine-10-carbothioic acid S-(2-dimethylaminoethyl) ester
10(9H)-Acridinecarbothioic acid, 9,9-dimethyl-, S-[2-(dimethylamino)ethyl] ester | [Molecular Formula]
C20H24N2OS | [MOL File]
4774-53-2.mol | [Molecular Weight]
340.48 |
| Hazard Information | Back Directory | [Originator]
Botiacrine,ZYF Pharm Chemical | [Manufacturing Process]
To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether,
a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was
added. After boiling for 1 hour, the reaction mixture was cooled to 0°C,
whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared
from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No.
426,821) were added and the mixture was heated for a further 6 hours to
boiling temperature. After cooling to ambient temperature, the precipitated
sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The
corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol
ester was immediately precipitated out of filtrate as
base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at
147°-150°C. | [Therapeutic Function]
Antiparkinsonian |
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