| Identification | Back Directory | [Name]
1,8-Naphthyridine-2-acetonitrile,alpha-(3-chlorophenyl)-5,7-bis(trifluoromethyl)-(9CI) | [CAS]
478043-30-0 | [Synonyms]
AMDE1
AMDE-1
AMDE 1
1,8-Naphthyridine-2-acetonitrile,alpha-(3-chlorophenyl)-5,7-bis(trifluoromethyl)-(9CI) | [Molecular Formula]
C18H8ClF6N3 | [MDL Number]
MFCD02082515 | [MOL File]
478043-30-0.mol | [Molecular Weight]
415.72 |
| Hazard Information | Back Directory | [Description]
AMDE-1 is a modulator of autophagy activity. It acts by triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation. | [Uses]
AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer[1]. | [References]
[1] Li M, et, al. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083. DOI:10.1371/journal.pone.0122083 |
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