| Identification | Back Directory | [Name]
2,5-Pyrrolidinedione, 1-[(5-azido-1-oxopentyl)oxy]- | [CAS]
478801-48-8 | [Synonyms]
N3-C4-NHS ester
2,5-dioxopyrrolidin-1-yl 5-azidopentanoate
5-Azidopentanoic acid N-hydroxysuccinimide ester
5-azidopentanoic acid N-hydroxysuccinimidyl ester
2,5-Pyrrolidinedione, 1-[(5-azido-1-oxopentyl)oxy]- | [Molecular Formula]
C9H12N4O4 | [MDL Number]
MFCD25963671 | [MOL File]
478801-48-8.mol | [Molecular Weight]
240.216 |
| Hazard Information | Back Directory | [Uses]
N3-C4-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507. DOI:10.1021/acs.jmedchem.7b00736 |
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