| Identification | Back Directory | [Name]
1-(8-CHLORO-10,11-DIHYDRODIBENZO[B,F]THIEPIN-10-YL)-4-METHYL-PIPERAZINE MALEATE | [CAS]
4789-68-8 | [Synonyms]
vufb-6281
OCTOCLOTHEPIN MALEATE
octoclothepinemaleate
OCTOCLOTHEPIN MALEATE SALT
OCTOCLOTHEPIN MALEATE D2 DOPAMINE ANTAGO NIS
8-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepinmaleate
1-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methyl-piperazinmale
d,l-8-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepinmaleate
1-(8-CHLORO-10,11-DIHYDRODIBENZO[B,F]THIEPIN-10-YL)-4-METHYL-PIPERAZINE MALEATE
Piperazine, 1-(8-chloro-10,11-dihydrodibenzo(B,F)thiepin-10-yl)-4-methyl-, maleate
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine maleate salt | [Molecular Formula]
C23H25ClN2O4S | [MDL Number]
MFCD00153855 | [MOL File]
4789-68-8.mol | [Molecular Weight]
460.97 |
| Chemical Properties | Back Directory | [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >21 mg/mL | [form ]
solid | [color ]
white | [InChI]
1S/C19H21ClN2S.C4H4O4/c1-21-8-10-22(11-9-21)17-12-14-4-2-3-5-18(14)23-19-7-6-15(20)13-16(17)19;5-3(6)1-2-4(7)8/h2-7,13,17H,8-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | [InChIKey]
GWKBZIADWSOIQV-BTJKTKAUSA-N | [SMILES]
[H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CCN(CC1)C2Cc3ccccc3Sc4ccc(Cl)cc24 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
36/37/39-45 | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [RTECS ]
TL1575000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Uses]
Octoclothepin Maleate Salt is an SR-2A inhibitor as well as a D2DR inhibitor. | [Biological Activity]
D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist. | [in vivo]
Octoclothepin possesses high cataleptogenic and anti-apomorphine activities in rats; it is able to exert full protection against apomorphine-induced emesis in dogs after the dose of 0.1 mg/kg s.c.[1].
Octoclothepin in doses of 0.5 and 1.5 mg/kg s.c. reduces the DA level and raises the HVA and DOPAC levels significantly[1].
|
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|