| Hazard Information | Back Directory | [Description]
IK-862 selectively inhibits TACE (ADAM17). | [Uses]
IK-862 is a selective inhibitor of TACE[1]. | [Definition]
ChEBI:(2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide is a hydroxamic acid, a member of quinolines and a member of pyrrolidin-2-ones. | [References]
[1] Georgiadis D, et al. Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008;16(19):8781-8794. doi:10.1016/j.bmc.2008.08.058 DOI:10.1016/j.bmc.2008.08.058 |
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