| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [color ]
White to off-white | [Sequence]
{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala |
| Hazard Information | Back Directory | [Uses]
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1]. | [in vivo]
MANS peptide (50 nmol/injection, ip, every 3 days for 6 injection) inhibits tumor metastasis, without affecting tumorigenesis in PC9 xenograft NOD/SCID mice model[1].
| Animal Model: | NOD/SCID mice model[1] | | Dosage: | 50 nmol/injection | | Administration: | Ip, every 3 days for 6 times | | Result: | Suppressed micrometastatic lesions. |
| [References]
[1] Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706. DOI:10.1038/onc.2013.336 |
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