| Identification | Back Directory | [Name]
Edoxaban (TsOH salt) | [CAS]
480449-71-6 | [Synonyms]
DU-176b
Edoxaban TsOH
Edoxaban tosylate
Edoxaban (TsOH salt)
Edoxaban tosylate
(DU-176b) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C31H38ClN7O7S2 | [MOL File]
480449-71-6.mol | [Molecular Weight]
720.26 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
25℃: DMSO | [form ]
Powder | [color ]
White to off-white | [InChIKey]
ZLFZITWZOYXXAW-BUZWFPPCNA-N | [SMILES]
S(C1C=CC(C)=CC=1)(O)(=O)=O.N([C@@H]1C[C@@H](C(=O)N(C)C)CC[C@@H]1NC(=O)C(=O)NC1N=CC(Cl)=CC=1)C(C1SC2CN(C)CCC=2N=1)=O |&1:12,14,22,r| |
| Hazard Information | Back Directory | [Uses]
Edoxaban tosylate (Lixiana; Daiichi Sankyo, Tokyo, Japan), known as DU-176b in clinical trials, is a novel oral direct factor Xa inhibitor. Edoxaban has good bioavailability with maximum plasma concentration achieved 1–2 h after ingestion and plasma half-life of 8–10 h. Edoxaban is a novel anticoagulant (NOAC) indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis and pulmonary embolism.
| [Definition]
ChEBI: An organosulfonate salt obtained by combining equimolar amounts of edoxaban and 4-toluenesulfonic acid. Used (in the form of its monohydrate) for the treatment of deep vein thrombosis and pulmonary embolism. | [in vivo]
Edoxaban tosylate (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT[1]. | Animal Model: | Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model)[1]. | | Dosage: | 0.5, 2.5 and 12.5 mg/kg | | Administration: | Oral administration; once | | Result: | Inhibited exogenous FXa activity.
Antithrombotic. |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
BePharm Ltd
|
| Telephone: |
400-685-9117 |
| Website: |
www.bepharm.com |
|