| Identification | Back Directory | [Name]
Hydrazinecarboxylic acid, 2-(4-chlorophenyl)-, phenyl ester | [CAS]
480452-24-2 | [Synonyms]
Antibiofilm agent-12
Hydrazinecarboxylic acid, 2-(4-chlorophenyl)-, phenyl ester | [Molecular Formula]
C13H11ClN2O2 | [MOL File]
480452-24-2.mol | [Molecular Weight]
262.69 |
| Hazard Information | Back Directory | [Uses]
Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model[1]. | [References]
[1] Fatima T, et al. Exploring the antifungal potential of novel carbazate derivatives as promising drug candidates against emerging superbug, Candida auris. Bioorg Chem. 2024 Sep 4;153:107782. DOI:10.1016/j.bioorg.2024.107782 |
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