| Identification | Back Directory | [Name]
endocrocin | [CAS]
481-70-9 | [Synonyms]
endocrocin
1,6,8-Trihydroxy-3-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
9,10-Dihydro-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracenecarboxylic acid
2-Anthracenecarboxylic acid, 9,10-dihydro-1,6,8-trihydroxy-3-methyl-9,10-dioxo- | [Molecular Formula]
C16H10O7 | [MOL File]
481-70-9.mol | [Molecular Weight]
314.25 |
| Chemical Properties | Back Directory | [Melting point ]
318 °C (decomp)(Solv: acetic acid (64-19-7)) | [Boiling point ]
679.7±55.0 °C(Predicted) | [density ]
1.715±0.06 g/cm3(Predicted) | [pka]
1.63±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
Endocrocin, an anthraquinone, is a fungal secondary metabolite. Endocrocin is a potent chemotaxis inhibitor with immunosuppressive properties[1][2]. | [Definition]
ChEBI: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by a carboxy group at position 2, a methyl group at position 3, and hydroxy groups at positions 1, 6, and 8. | [References]
[1] Berthier E, et al. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 2013;9(4):e1003289. DOI:10.1371/journal.ppat.1003289
[2] Lim FY, et al. Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Appl Environ Microbiol. 2012 Jun;78(12):4117-25. DOI:10.1128/AEM.07710-11 |
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