| Identification | Back Directory | [Name]
Chimaphilin | [CAS]
482-70-2 | [Synonyms]
7-Dimethyl-1
2,7-Dimethyl-1,4-naphthalenedione
2,7-dimethylnaphthalene-1,4-dione
1,4-Naphthalenedione, 2,7-dimethyl- | [Molecular Formula]
C12H10O2 | [MOL File]
482-70-2.mol | [Molecular Weight]
186.21 |
| Hazard Information | Back Directory | [Uses]
Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2]. | [Definition]
ChEBI: Chimaphylin is a member of 1,4-naphthoquinones. | [References]
[1] Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. DOI:10.1016/j.cbi.2015.05.008
[2] Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8. DOI:10.1016/j.fct.2014.04.014 |
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