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483-10-3

483-10-3 Structure

483-10-3 Structure
IdentificationBack Directory
[Name]

CORYNANTHINE
[CAS]

483-10-3
[Synonyms]

Nsc407306
Rauhimbin
RAUHIMBINE
Corynanthin
Coynanthine
CORYNANTHINE
CORYNANTHINE HCL(RG)
CORYNANTHINE DIHYDRATE
corynanthine free base
methyl (16beta,17alpha)-17-hydroxyyohimban-16-carboxylate
17ALPHA-HYDROXYYOHIMBAN-16BETA-CARBOXYLIC ACID METHYL ESTER
Yohimban-16.beta.-carboxylic acid, 17.alpha.-hydroxy-, methyl ester
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16.beta.,17.alpha.)-
[EINECS(EC#)]

207-590-0
[Molecular Formula]

C21H26N2O3
[MDL Number]

MFCD00069659
[MOL File]

483-10-3.mol
[Molecular Weight]

354.44
Chemical PropertiesBack Directory
[Melting point ]

225-230°C
[alpha ]

D19 -85° (c = 0.5 in pyridine)
[storage temp. ]

2-8°C
[LogP]

2.200 (est)
Safety DataBack Directory
[Risk Statements ]

25
[Safety Statements ]

1-20-45
[RIDADR ]

1544
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

This alkaloid has been isolated by Hoffmann from the bark of Rauwolfia serpentina. It forms colourless crystals from Me2CO and has [α]20D - 82° (c 0.5, pyridine).
[Uses]

Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits[1].
[Definition]

ChEBI:Corynanthine is a yohimban alkaloid.
[References]

Hoffmann., Helv. Chim. Acta, 37,314,849 (1954)
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