| Identification | Back Directory | [Name]
SB-674042 | [CAS]
483313-22-0 | [Synonyms]
SB-674042
SB 674042; SB674042
SB-674042, CID10204153
SB 674042 >=98% (HPLC)
[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone
Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-
(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone
(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI)
[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE | [Molecular Formula]
C24H21FN4O2S | [MDL Number]
MFCD18251550 | [MOL File]
483313-22-0.mol | [Molecular Weight]
448.51 |
| Chemical Properties | Back Directory | [Boiling point ]
655.9±65.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
0.74±0.10(Predicted) | [color ]
white to beige | [InChIKey]
HYBZWVLPALMACV-KRWDZBQOSA-N | [SMILES]
Fc1c(cccc1)c2[s]c(nc2C(=O)N3[C@@H](CCC3)Cc4nnc([o]4)c5ccccc5)C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
SB 674042 is a novel nonpeptide antagonist to OX-1. | [Biochem/physiol Actions]
SB-674042 is potent and selective OX1R antagonist. SB-674042 binds with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells. | [in vivo]
SB-674042 (0.3 nM/0.3 μL; icv; single dose) reduces contextual and cues fear freezing responses in Stay animals in Stress Alternatives Model (SMA) in mice[4].
| Animal Model: | Stress-induced mice model (male C57BL/6NHsd mice, 22-26 g)[4] | | Dosage: | 0.3 nM/0.3 μL | | Administration: | Intracerebroventricular injection; subjected mice to 4 days of social aggression (days 1-4) | | Result: | Resulted 39.4% Escape and 60.6% Stay phenotypes among mice. |
| [IC 50]
OX1 Receptor: 3.76 nM (IC50); OX2 Receptor: 531 nM (IC50); OX1 Receptor: 1.1 nM (Ki); OX2 Receptor: 129 nM (Ki) | [storage]
Store at +4°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|