| Identification | Back Directory | [Name]
DICTAMNINE | [CAS]
484-29-7 | [Synonyms]
dictamine
DICTAMNINE
Dictamnine ,98%
3-b)quinoline,4-methoxy-furo(
4-Methoxyfuro[2,3-b]quinoline
Dictamnine
4-Methoxyfuro[2,3-b]quinoline | [Molecular Formula]
C12H9NO2 | [MDL Number]
MFCD00221742 | [MOL File]
484-29-7.mol | [Molecular Weight]
199.21 |
| Chemical Properties | Back Directory | [Melting point ]
133° | [Boiling point ]
336.72°C (rough estimate) | [density ]
1.1919 (rough estimate) | [refractive index ]
1.5880 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
7.24±0.40(Predicted) | [color ]
Light Beige | [CAS DataBase Reference]
484-29-7 |
| Hazard Information | Back Directory | [Uses]
antifungal, vasal relaxant, mooth muscle contractant | [Chemical Properties]
Soluble in hot ethanol and chloroform, slightly soluble in ether, and insoluble in water. It comes from the root of Dictamnus dasycarpus Turcz., a plant of the Rutaceae family. | [Definition]
ChEBI: Dictamnine is an oxacycle, an organonitrogen heterocyclic compound, an organic heterotricyclic compound and an alkaloid antibiotic. | [Synthesis Reference(s)]
Tetrahedron Letters, 14, p. 843, 1973 DOI: 10.1016/S0040-4039(01)95731-4 | [in vivo]
Dictamine (2 μg/mL, 200 μL, applied once daily, for 14 days) reduces skin inflammation and skin swellingin Oxazolone (HY-126360)-induced atopic dermatitis mice model[2].
Dictamine (50 and 100 mg/kg, p.o., three times a week) inhibits tumor growth in a HCT116 xenograft tumor model[3].
Dictamine (1 and 5 mg/kg, 200 μL, applied to the skin) ameliorates chronic itch in 2,4-dinitrofluorobenzene-induced atopic dermatitis mice[4].
| Animal Model: | HCT116 xenograft tumor model[3] | | Dosage: | 50 and 100 mg/kg | | Administration: | p.o., three times a week | | Result: | Inhibited tumor growth.
Reduced HIF-1α and Slug protein level in the tumor tissue. |
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