| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
≥ 100.9mg/mL in DMSO | [form ]
Solid | [pka]
12.56±0.70(Predicted) | [color ]
White to off-white | [Sequence]
Pro-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Lys-NH2 (disulfide bridge: Cys2-Cys7) |
| Hazard Information | Back Directory | [Uses]
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. | [IC 50]
GHSR1a | [References]
[1] F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42(1):89-93. DOI:10.1016/j.npep.2007.09.006 |
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