| Identification | Back Directory | [Name]
2-NITRO-N-[[TRANS-4-[[[(1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)METHYL]AMINO]METHYL]CYCLOHEXYL]METHYL]BENZENESULFONAMIDE HYDROCHLORIDE | [CAS]
486453-65-0 | [Synonyms]
NTNCB HYDROCHLORIDE
Benzenesulfonamide, 2-nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]-
2-NITRO-N-[[TRANS-4-[[[(1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)METHYL]AMINO]METHYL]CYCLOHEXYL]METHYL]BENZENESULFONAMIDE HYDROCHLORIDE | [Molecular Formula]
C25H33N3O4S | [MDL Number]
MFCD07783996 | [MOL File]
486453-65-0.mol | [Molecular Weight]
471.61 |
| Chemical Properties | Back Directory | [Boiling point ]
638.407±61.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.200±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at RT | [pka]
10.330±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
NTNCB Hydrochloride was used to study DNA encodoing a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5). | [Biological Activity]
Selective, non-peptide competitive NPY Y 5 antagonist. K i values are 8.0 and 16032 nM at human recombinant Y 5 and Y 1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D 2 and α 2C receptors (K i values are 63 and 100 nM respectively). |
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