| Identification | Back Directory | [Name]
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine | [CAS]
486460-20-2 | [Synonyms]
3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE
1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)-
3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC) | [Molecular Formula]
C6H3F3N4 | [MDL Number]
MFCD09029664 | [MOL File]
486460-20-2.mol | [Molecular Weight]
188.11 |
| Hazard Information | Back Directory | [Uses]
3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine can be used as reactant/reagent in synthetic preparation of 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for treatment or prevention of diabetes. | [Synthesis]
General method: 10 mmol of compound 3 (CAS:1447800-65-8) was dissolved in 50 mL of toluene and 20 mmol of triethylamine was slowly added to the reaction system at room temperature with continuous stirring for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). After the reaction was complete, the reaction mixture was slowly poured into 25 g of ice-water mixture, stirred thoroughly and left to stratify. The organic phase was separated and washed with 2 x 10 mL of cold water, followed by drying the organic phase with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give compound 4 in good yield. | [References]
[1] Letters in Organic Chemistry, 2013, vol. 10, # 5, p. 348 - 352 |
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