| Identification | Back Directory | [Name]
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone | [CAS]
487-49-0 | [Synonyms]
Ononetin
2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone
4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-
2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin)
Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin | [Molecular Formula]
C15H14O4 | [MDL Number]
MFCD00020119 | [MOL File]
487-49-0.mol | [Molecular Weight]
258.28 |
| Chemical Properties | Back Directory | [Melting point ]
158.0 to 162.0 °C | [Boiling point ]
464.7±14.0 °C(Predicted) | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
7.65±0.35(Predicted) | [color ]
White to Light yellow to Dark green |
| Hazard Information | Back Directory | [Uses]
Ononetin is a potent and selective transient receptor potential TRMP3 blocker and may represent a novel concept for analgesic treatment. | [Definition]
ChEBI: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone is a stilbenoid. | [Preparation]
Preparation by condensation of p-methoxyphenyl-acetonitrile with resorcinol (Hoesch reaction). | [in vivo]
Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain[2]. | [IC 50]
TRPM3: 0.3 μM (IC50) | [storage]
Store at -20°C |
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TCI Europe
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| Company Name: |
TCI AMERICA
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800-4238616 |
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