| Identification | Back Directory | [Name]
UC-857993 | [CAS]
487001-04-7 | [Synonyms]
UC-857993
Benzo[ij]dicyclopenta[b,g]quinolizine-2-carboxylic acid, 7-(2-chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydro- | [Molecular Formula]
C25H22ClNO2 | [MOL File]
487001-04-7.mol | [Molecular Weight]
403.9 |
| Hazard Information | Back Directory | [Uses]
UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1]. | [References]
[1] Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. DOI:10.1074/jbc.M114.634493 |
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