| Identification | Back Directory | [Name]
4-(dimethylammonio)piperidinium dichloride | [CAS]
4876-59-9 | [Synonyms]
EOS-62283
ammonio)piperidinium dichL
4-DIMETHYLAMINOPIPERIDINE 2HCL
DiMethyl-piperidin-4-yl-aMine di, HCl
4-(dimethylammonio)piperidinium dichloride
4-(Dimethylamino)piperidine dihydrochloride
4-(diMethylaMino)-piperidine dihydorochloride
Dimethyl-piperidin-4-yl-amine dihydrochloride
N,N-dimethylpiperidin-4-amine dihydrochloride
Dimethyl-piperidin-4-yl-amine dihydorochloride
4-(Dimethylamino)piperidine dihydrochloride,98%
4-(dimethylammonio)piperidinium dichloride ISO 9001：2015 REACH | [EINECS(EC#)]
225-486-3 | [Molecular Formula]
C7H18Cl2N2 | [MDL Number]
MFCD00035296 | [MOL File]
4876-59-9.mol | [Molecular Weight]
201.137 |
| Chemical Properties | Back Directory | [Melting point ]
288-290℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to yellow Solid | [InChI]
InChI=1S/C7H16N2.ClH/c1-9(2)7-3-5-8-6-4-7;/h7-8H,3-6H2,1-2H3;1H | [InChIKey]
IDCJGSDAPFXTGB-UHFFFAOYSA-N | [SMILES]
N(C1CCNCC1)(C)C.Cl |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Dimethyl-piperidin-4-yl-amine DiHCl | [Synthesis]
General procedure for the synthesis of 4-dimethylaminopiperidine dihydrochloride from N-Boc-4-dimethylaminopiperidine: 10.0 g of tert-butyl 4-(dimethylamino)piperidine-1-carboxylate (0.044 mol) was dissolved in 60 mL of dichloromethane and cooled in an ice bath. Subsequently, 4 mol/L of HCl/dioxane solution (34.5 mL, 0.138 mol) was slowly added, and stirring was maintained during the dropwise addition. The reaction mixture was continued to be stirred under ice bath conditions for 8 hours. Upon completion of the reaction, a large amount of white solid precipitate was observed to be generated, and the precipitate was collected by filtration and washed with a small amount of cold dichloromethane to remove residual HCl. 6.4 g of the target product, 4-dimethylaminopiperidine dihydrochloride, was finally obtained in 85.3% yield. | [References]
[1] Patent: CN108456183, 2018, A. Location in patent: Paragraph 0020; 0101-0103
[2] Synthetic Communications, 2009, vol. 39, # 2, p. 273 - 277 |
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