| Identification | Back Directory | [Name]
[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid | [CAS]
491-97-4 | [Synonyms]
5'-TDP
Deoxy-tdp
Thymidine Impurity 4
Tirofiban Impurity 74
Thymidine diphosphate
Thymidine pyrophosphate
Thymidine 5'-pyrophosphate
2'-Deoxythymidine 5'-diphosphate
Thymidine 5'-(trihydrogen diphosphate)
Thymidine 5'-(trihydrogen diphosphate) (9ci)
[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-oxolan-2-yl]methoxy]phosphoryl]oxyphosphonic acid | [Molecular Formula]
C10H16N2O11P2 | [MDL Number]
MFCD20488860 | [MOL File]
491-97-4.mol | [Molecular Weight]
402.19 |
| Hazard Information | Back Directory | [Uses]
Thymidine 5′-diphosphate (dTDP) is the key product of pyrimidine synthesis in organisms. Thymidine 5′-diphosphate is produced by thymidylate kinase (TMPK) catalyzed phosphorylation of 5′-thymidine monophosphate (dTMP), which requires ATP and Mg2+. Thymidine 5′-diphosphate is further catalyzed by TMPK to thymidine 5′-triphosphate (dTTP). TMPK activity can be detected by measuring the level of Thymidine 5′-diphosphate[1][2]. | [Definition]
ChEBI: A thymidine phosphate having a diphosphate group at the 5'-position. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Cui Q, et al. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. DOI:10.2174/0929867311320100006
[2] Tzeng HF, et al. Simultaneous determination of thymidylate and thymidine diphosphate by capillary electrophoresis as a rapid monitoring tool for thymidine kinase and thymidylate kinase activities. Electrophoresis. 2005 Jun;26(11):2225-30. DOI:10.1002/elps.200410091 |
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