| Identification | Back Directory | [Name]
HEMOKININ 1 (HUMAN) | [CAS]
491851-53-7 | [Synonyms]
HHK-1
HK-1 (HUMAN)
HEK-1 (HUMAN)
HEMOKININ 1 (HUMAN)
HK-1 (huMan), HEK-1 (huMan)
Hemokinin 1 human >=98% (HPLC), solid
Hemokinin 1 (human) trifluoroacetate salt
THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2
HeMokinin 1 (huMan)
HK-1 (huMan), HEK-1 (huMan)
H-THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2
L-Methioninamide, L-threonylglycyl-L-lysyl-L-alanyl-L-seryl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide | [Molecular Formula]
C54H84N14O14S | [MDL Number]
MFCD06656083 | [MOL File]
491851-53-7.mol | [Molecular Weight]
1185.4 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Water: soluble | [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble to 0.70 mg/ml in water | [Sequence]
H-Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2 | [InChIKey]
NYBLUYYRUFKGTB-XJCFQSCISA-N |
| Hazard Information | Back Directory | [Uses]
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia[1][2]. | [Biological Activity]
Hemokinin 1 (HK1) is an endogenous agonist for all tachykinin receptors. Howeverit is highly selective for the NK1 (neurokinin 1) receptor. HK1 and substance-P compete with each other for binding to NK1. HK1 is involved in the B-cell as well as T-cell development.''NK1 tachykinin receptor agonist. | [IC 50]
NK1; NK2; NK3 | [References]
[1] Cai-Yun Fu, et al. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One DOI:10.1371/journal.pone.0090446
[2] Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan;135(1):266-74. DOI:10.1038/sj.bjp.0704443 |
|
|