| Identification | Back Directory | [Name]
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE | [CAS]
493028-20-9 | [Synonyms]
CBFβInhibitor
CBFβ Inhibitor
TIMTEC-BB SBB011699
Runx1-CBFβ interaction inhibitor 1
2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine | [Molecular Formula]
C12H14N2OS | [MDL Number]
MFCD02232182 | [MOL File]
493028-20-9.mol | [Molecular Weight]
234.32 |
| Chemical Properties | Back Directory | [Boiling point ]
421.6±40.0 °C(Predicted) | [density ]
1.192±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml | [form ]
Tan solid | [pka]
5.00±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. | [Uses]
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity. | [References]
[1] KEVIN A. LINK James C M Fu Sheng Chou. Core binding factor at the crossroads: Determining the fate of the HSC?[J]. Journal of Cellular Physiology, 2009, 222 1: 50-56. DOI: 10.1002/jcp.21950
[2] GEMMA SWIERS Nancy A S Marella de Bruijn. Hematopoietic stem cell emergence in the conceptus and the role of Runx1.[J]. International Journal of Developmental Biology, 2010, 54 6-7: 1151-1163. DOI: 10.1387/ijdb.103106gs
[3] MICHAEL J GORCZYNSKI. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.[J]. Chemistry & biology, 2007, 14 10: 1186-1197. DOI: 10.1016/j.chembiol.2007.09.006 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|