| Identification | Back Directory | [Name]
L-Glutamic acid, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-threonyl-L-seryl-L-phenylalanyl-L-alanyl- | [CAS]
496856-73-6 | [Synonyms]
GSK3β-peptide
L-Glutamic acid, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-threonyl-L-seryl-L-phenylalanyl-L-alanyl- | [Molecular Formula]
C47H76N16O16 | [MOL File]
496856-73-6.mol | [Molecular Weight]
1121.2 |
| Hazard Information | Back Directory | [Uses]
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs[1]. | [References]
[1] Kayser, et al. "Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics." Bioorganic & medicinal chemistry letters 17.7 (2007): 2068-2073. DOI:10.1016/j.bmcl.2007.01.004 |
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