| Identification | Back Directory | [Name]
H-GLY-NHME HCL | [CAS]
49755-94-4 | [Synonyms]
H-Gly-NHMe
Gly-NHMe·HCl
H-GLY-NHME HCL
GLYCINE-NHME HCL
H-Gly-nhme hydrochloride
H-GLY-NHME HCL USP/EP/BP
2-AMino-N-Methyl-acetaMide HCl
2-AMINO-N-METHYLACETAMIDE HYDR
GLYCINE METHYLAMIDE HYDROCHLORIDE
N-Methylglycinamide hydrochloride
GLYCINE-N-METHYLAMIDE HYDROCHLORIDE
Glycine-N-methylamidehydrochloride,97%
2-AMINO-N-METHYLACETAMIDE HYDROCHLORIDE
Acetamide,2-amino-N-methyl-, hydrochloride (1:1)
N-Methyl-glycine amide, 2-Amino-N-methylacetamide hydrochloride | [Molecular Formula]
C3H9ClN2O | [MDL Number]
MFCD00153440 | [MOL File]
49755-94-4.mol | [Molecular Weight]
124.57 |
| Hazard Information | Back Directory | [Uses]
2-Amino-N-methylacetamide is an intermediate used to prepare macrocyclic hydroxamic acids that inhibit tumor necrosis factor α. It is also used to synthesize 2-[(arylalkyl)amino]alkanamide derivatives with anticonvulsant activities. | [Synthesis]
Tert-butyl N-[(methylcarbamoyl)methyl]carbamate (300 mg, 1.59 mmol, 1.00 eq.) was dissolved in dichloromethane (5 mL), hydrochloric acid (1.2 mL) was added, and the reaction was stirred for 4 hours at room temperature. After completion of the reaction, the mixture was concentrated under vacuum to give 2-amino-N-methylacetamide hydrochloride (185 mg), the product was a colorless oil. Mass spectrum (MS): m/z 89 (M + H)+. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3): δ 8.45 (br s, 1H), 8.19 (s, 3H), 3.50 (d, 2H), 2.65 (d, 3H). | [References]
[1] Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4834 - 4843
[2] Journal de Chimie Physique et de Physico-Chimie Biologique, 1988, vol. 85, # 5, p. 583 - 588
[3] Patent: WO2013/106535, 2013, A1. Location in patent: Paragraph 00571 |
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