| Identification | Back Directory | [Name]
GUVACINE HYDROCHLORIDE | [CAS]
498-96-4 | [Synonyms]
GUVACINE
GUVACINE-HCL
GUVACINE HYDROCHLORIDE
1,2,5,6-tetrahydronicotinic acid
1,2,3,6-tetrahydropyridine-5-carboxylic acid
1,2,5,6-Tetrahydropyridine-3-carboxylic acid
1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-
1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
1,2,5,6-tetrahydropyridine-3-carboxylic acid(SALTDATA: HCl) | [Molecular Formula]
C6H10ClNO2 | [MDL Number]
MFCD00055191 | [MOL File]
498-96-4.mol | [Molecular Weight]
163.6 |
| Chemical Properties | Back Directory | [Melting point ]
295°C (rough estimate) | [Boiling point ]
235.91°C (rough estimate) | [density ]
1.1931 (rough estimate) | [refractive index ]
1.4645 (estimate) | [storage temp. ]
Store at RT | [solubility ]
H2O: soluble
| [form ]
solid
| [pka]
3.61±0.20(Predicted) | [color ]
white
| [InChI]
InChI=1S/C6H9NO2/c8-6(9)5-2-1-3-7-4-5/h2,7H,1,3-4H2,(H,8,9) | [InChIKey]
QTDZOWFRBNTPQR-UHFFFAOYSA-N | [SMILES]
C1NCCC=C1C(O)=O | [CAS DataBase Reference]
498-96-4 |
| Hazard Information | Back Directory | [Definition]
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. | [Biological Activity]
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. | [Uses]
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders. | [storage]
Store at -20°C |
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