| Identification | Back Directory | [Name]
AVE 0118 hydrochloride | [CAS]
498577-53-0 | [Synonyms]
AVE-0118
AVE-0118
(AVE0118)
AVE 0118 hydrochloride
[1,1'-Biphenyl]-2-carboxamide, 2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]- | [Molecular Formula]
C30H29N3O3 | [MDL Number]
MFCD28502274 | [MOL File]
498577-53-0.mol | [Molecular Weight]
479.57 |
| Hazard Information | Back Directory | [Uses]
AVE-0118 is a nonselective Kv1.5 blocker with an IC50 of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against IKs, IKATP, and L-type Ca+ channels[1]. | [in vivo]
AVE-0118 reduces the inducibility of AF in goats with remodeled atria at a dose of 3 mg/kg and did not prolong QTc up to 5 mg/kg[1]. | [References]
[1] Bilodeau MT, et al. Kv1.5 blockers for the treatment of atrial fibrillation: approaches to optimization of potency and selectivity and translation to in vivo pharmacology. Curr Top Med Chem. 2009;9(5):436-51. DOI:10.2174/156802609788340832
[2] Kun A, et al. Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries. Basic Clin Pharmacol Toxicol. 2014 Oct;115(4):315-20. DOI:10.1111/bcpt.12225 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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