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EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC50 value of 67 nM[1]. | [References]
[1] Asada M, et al. 3-(2-Aminocarbonylphenyl) propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 2: Optimization of the side chains to improve in vitro and in vivo potencies[J]. Bioorganic & medicinal chemistry, 2010, 18(4): 1641-1658. DOI:10.1016/j.bmc.2009.12.068 |
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