| Identification | Back Directory | [Name]
Fluphenazine decanoate | [CAS]
5002-47-1 | [Synonyms]
lyogen
modecate
sq10,733
dapotumd
ecanoate
moditendepot
zinyl)ethylester
prolixindecanoate
fluphenazinedepot
flufenazinedecanoate
FLUPHENAZINEDECANATE
FluphenazineCecanoate
FLUPHENAZINE DECANOATE
fluphenazine o-decanoate
fluorophenazinedecanoate
Decanoic acid fluphenazine
2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyld
decanoicacid,2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-pipera
2-[4-[3-(2-(TRIFLUOROMETHYL)PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHYL DECANOATE
2-(4-(3-(2-(trifluoroMethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl decanoate
Decanoic acid 2-[4-[3-(2-trifluoromethyl-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethyl ester
Decanoic acid, 2-[4-[3-[2-(trifluoromethyl) -10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester | [EINECS(EC#)]
225-672-4 | [Molecular Formula]
C32H44F3N3O2S | [MDL Number]
MFCD00798504 | [MOL File]
5002-47-1.mol | [Molecular Weight]
591.77 |
| Chemical Properties | Back Directory | [Melting point ]
30-32° | [Boiling point ]
658.1±55.0 °C(Predicted) | [density ]
1.149±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol. | [form ]
neat | [pka]
7.32±0.10(Predicted) | [color ]
Light yellow to yellow | [CAS DataBase Reference]
5002-47-1 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Oil | [Uses]
Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic. | [Definition]
ChEBI:Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine. | [Clinical Use]
AntipsychoticSchizophrenia and other psychoses | [Drug interactions]
Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with
tramadol; enhanced hypotensive and sedative effects
with opioids. Anti-arrhythmics: increased risk of ventricular
arrhythmias with anti-arrhythmics that prolong
the QT interval; increased risk of ventricular
arrhythmias with amiodarone and dronedarone -
avoid; increased risk of ventricular arrhythmias with
disopyramide.Antibacterials: increased risk of ventricular
arrhythmias with delamanid and moxifloxacin -
avoid Antidepressants: increased risk of ventricular
arrhythmias with tricyclics, citalopram, escitalopram;
possible increased risk of convulsions with
vortioxetineAntiepileptics: antagonises anticonvulsant effect.Antimalarials: increased risk of ventricular
arrhythmias with artenimol with piperaquine and
artemether/lumefantrine - avoid.Antipsychotics: increased risk of ventricular
arrhythmias with droperidol, pimozide and
risperidone - avoid; avoid use of depot formulations
with clozapine (cannot be withdrawn quickly if
neutropenia occurs).Antivirals: increased risk of ventricular arrhythmias
with saquinavir - avoid; concentration possibly
increased with ritonavir.Anxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular
arrhythmias.Beta-blockers: enhanced hypotensive effect;
increased risk of ventricular arrhythmias with sotalolCytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxideDiuretics: enhanced hypotensive effect.Lithium: increased risk of extrapyramidal side effects
and possibly neurotoxicity.Pentamidine: increased risk of ventricular
arrhythmias - avoid.Avoid with drugs that prolong the QT interval. | [Metabolism]
The cytochrome P450 isoenzyme CYP2D6 is involved in
fluphenazine metabolism. | [storage]
Store at -20°C |
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