| Identification | Back Directory | [Name]
MK0873 | [CAS]
500355-52-2 | [Synonyms]
MK0873
1,8-Naphthyridine-3-carboxamide,N-cyclopropyl-1,4-dihydro-1-[3-[(1-oxido-3-pyridinyl)ethynyl]phenyl]-4-oxo-
1,8-Naphthyridine-3-carboxamide, N-cyclopropyl-1,4-dihydro-1-[3-[2-(1-oxido-3-pyridinyl)ethynyl]phenyl]-4-oxo- | [Molecular Formula]
C25H18N4O3 | [MDL Number]
MFCD20488866 | [MOL File]
500355-52-2.mol | [Molecular Weight]
422.44 |
| Hazard Information | Back Directory | [Uses]
MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the PDE4 enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD)[1]. | [IC 50]
PDE4 | [References]
[1] Boot J D, et al. MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers[J]. Pulmonary Pharmacology & Therapeutics, 2008, 21(3): 573-577. DOI:10.1016/j.pupt.2008.01.009 |
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