| Identification | Back Directory | [Name]
1-N,4-N-bis[3-(1H-benzimidazol-2-yl)phenyl]benzene-1,4-dicarboxamide | [CAS]
500538-94-3 | [Synonyms]
NSC61610
NSC-61610
NSC 61610
MLS000766212
SMR000528839
NSC61610 >=98% (HPLC)
1-N,4-N-bis[3-(1H-benzimidazol-2-yl)phenyl]benzene-1,4-dicarboxamide | [Molecular Formula]
C34H24N6O2 | [MDL Number]
MFCD28951968 | [MOL File]
500538-94-3.mol | [Molecular Weight]
548.59 |
| Chemical Properties | Back Directory | [density ]
1.410±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
11.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
NSC61610 is a LANCL2 ligand. NSC61610 showed anti-inflammatory activity and potential useful for inflammatory bowel disease and influenza-driven inflammation . LANCL2 is a novel therapeutic target for the discovery and development of new classes of orally active drugs against chronic metabolic, immune-mediated and infectious diseases. | [Uses]
NSC61610 disrupts hIL-18 binding to the ectromelia virus IL-18BP. NSC61610 inhibits hIL-18:ectvIL-18BP complex formation with an IC50 about 6?uM[1]. | [References]
[1] Krumm B, et al. Identification of small molecule inhibitors of Interleukin-18. Sci Rep. 2017 Mar 28;7(1):483. DOI:10.1038/s41598-017-00532-x |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|