| Identification | Back Directory | [Name]
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid | [CAS]
500577-51-5 | [Synonyms]
Cyclo(-RGDfK) Trifluoroacetate
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid | [Molecular Formula]
C29H42F3N9O9 | [MOL File]
500577-51-5.mol | [Molecular Weight]
717.694 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: 100 mg/mL (139.34 mM) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 33.33 mg/mL (46.44 mM) | [Sequence]
Cyclo(Arg-Gly-Asp-Phe-Lys) |
| Hazard Information | Back Directory | [Uses]
Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3]. | [IC 50]
αvβ3: 0.94 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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