| Identification | Back Directory | [Name]
deMethoxydeacetoxypseudolaric acid B | [CAS]
500736-17-4 | [Synonyms]
Demethoxydeacetoxypseudolaric acid B analog
1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-ethyl ester, (3R,4S,4aS,9aR)- | [Molecular Formula]
C24H30O8 | [MDL Number]
MFCD20260469 | [MOL File]
500736-17-4.mol | [Molecular Weight]
446.49 |
| Chemical Properties | Back Directory | [Boiling point ]
621.9±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.52±0.19(Predicted) |
| Questions And Answer | Back Directory | [Application]
Demethoxydeacetylated phloem acetic acid can be used as a pharmaceutical synthesis intermediate. Phloem acetic acid compounds and their new derivatives can inhibit the growth of human microvascular endothelial cells. Therefore, they can inhibit the division and proliferation of tumor cells by inhibiting the formation of blood vessels in tumor tissue (the malignant proliferation of tumors depends on the growth of blood vessels in tumor tissue), thereby reducing the supply of oxygen and nutrients required by tumor cells, leading to tumor shrinkage or even disappearance. |
| Hazard Information | Back Directory | [Synthesis]
In the reaction flask containing the above crude product, 10 ml of acetyl chloride was added, the electromagnetic stirrer was turned on, the reaction flask was sealed, and the reaction was followed up by TLC every 1 hour, and the reaction was finished aft |
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